Total Recall: Best Luc Besson Productions

After watching Jason Statham steal scenes in Lock, Stock, and Two Smoking Barrels and Snatch, Besson gave him the lead in The Transporter, a bullet-riddled thriller about Frank Martin, a guy who, well, transports things -- including illegal cargo for some pretty nasty people, no questions asked. Frank's first adventure revolves around a conspiracy to kidnap and "import" a few dozen Chinese people, and although it builds to a predictably loud and ridiculous conclusion, a number of critics still had plenty of fun getting there. As Steven Rea asked for the Philadelphia Inquirer, "It remains to be seen whether Statham can move beyond the crime-land action genre, but then again, who says he has to?"

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New MRI technique may predict progress of dementias

ScienceDaily (Apr. 10, 2012) ? A new technique for analyzing brain images offers the possibility of using magnetic resonance imaging (MRI) to predict the rate of progression and physical path of many degenerative brain diseases, report scientists at the San Francisco VA Medical Center and the University of California, San Francisco.

The technique, developed by SFVAMC scientists in collaboration with a team led by Bruce Miller, MD, clinical director of the UCSF Memory and Aging Center, also supports mounting evidence that dementias spread through the brain along specific neuronal pathways in the same manner as prion diseases.

The scientists employed new computer modeling techniques to realistically predict the physical progression of Alzheimer's disease and frontotemporal dementia (FTD) using images of 14 healthy brains. The models were based on whole-brain tractography, an MRI technique that maps the neural pathways, or "communication wires," that connect different areas of the brain. The spread of disease along those pathways, as predicted by the models, closely matched actual MRI images of brain degeneration in 18 Alzheimer's patients and 18 FTD patients.

Their study was published in the March 22 edition of Neuron.

"The results need to be replicated, but they suggest that, by using this approach, we can predict the location and course of future brain atrophy in Alzheimer's, FTD and other degenerative brain diseases, based on just one MRI taken at the outset of the disease," said senior author Michael Weiner, MD, director of the SFVAMC Center for Imaging of Neurodegenerative Diseases. "This would be extremely useful in planning treatment, and in helping patients and families know what to expect as dementia progresses."

Weiner, who is also a UCSF professor of radiology, medicine, psychiatry and neurology, said that the results were "consistent with an emerging concept that brain damage occurs in these neurodegenerative diseases in a diffusive, prion-like propagation."

A prion is an infectious, misfolded form of a normal protein. These proteins leave destructive amyloid deposits in the brains in which they develop, causing degeneration and eventual death. They are responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, or "mad cow" disease, in cattle. In 1997, neurologist Stanley B. Prusiner of UCSF was awarded the Nobel Prize in Medicine for discovering and characterizing the prion. His finding overturned a tenet of modern biology, showing that a protein, rather than just the molecules DNA and RNA, could cause infection.

"The idea of a prion-like mode of progression in dementias, which many scientists are beginning to support, is that the misfolded protein in one neuron will infect a neighboring brain cell, causing proteins in that cell to misfold in turn, and that the spread of these misfolded proteins flows along certain networks in the brain," explained Weiner. "For instance, in Alzheimer's, there is a spread of amyloid protein along the memory network. This paper reinforces the idea that the damage occurs progressively along that network and others."

Weiner emphasized that Alzheimer's and frontotemporal dementia "are not infectious diseases" like Creutzfeldt-Jakob. But he said "it may be that a little seed of the disease begins in one neuron in the brain and spreads in a similar way -- so it's infectious within the brain, from one neuron to the next."

The lead author of the paper is Ashish Raj, PhD, of SFVAMC and UCSF at the time of the study and currently at Weill Medical College, Cornell University, NY; the co-author is Amy Kuceyeski of Weill Cornell.

The study was supported by funds from the National Institutes of Health, some of which were administered by the Northern California Institute for Research and Education. The UCSF California Alzheimer's Disease Research Center also supported and contributed to the study.

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Story Source:

The above story is reprinted from materials provided by University of California - San Francisco. The original article was written by Steve Tokar.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Ashish Raj, Amy Kuceyeski, Michael Weiner. A Network Diffusion Model of Disease Progression in Dementia. Neuron, 2012; 73 (6): 1204 DOI: 10.1016/j.neuron.2011.12.040

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Jason Trawick Will Share Legal Control Over Britney Spears ...

Britney Spears and Jason Trawick. Photo: Kevin Mazur/WireImage/Getty Images

Britney Spears? father is making an extra effort to bond with his future son-in-law in an unusual way.? Jamie Spears is asking a court to add Jason Trawick as a co-conservator over his daughter, a source confirmed to People.? Jamie Spears, who?s has had legal control over his daughter?s multimillion dollar fortune since February 2008 after the pop singer suffered a psychological breakdown, plans for Trawick to have shared legal control over his Spears?s well being, but not her finances, according to the source.? While a conservator can make decisions over a person?s clothing, food and medical care, Spears will still have plenty of personal freedom.

How do you know when your spouse?s parents have accepted you?

Cupid?s Advice:

Being in love can be a wonderful feeling, and it?s even better when you have your partner?s parents blessing.? Here are a few ways to tell when your spouse?s parents have accepted you:

1. They enjoy your company:?When your lover?s parents are beating him or her to the punch when calling you to come over for game nights and family dinners, it sounds like you?re a shoe-in and their parents would love to see their son or daughter settle down with someone like you.

2. They brag about you:?Meeting your spouse?s parents can be hard enough, but when you have to meet an entire family, that can definitely turn you into a nervous wreck.? But, when your spouse?s parents have bragged and told everyone what a wonderful person you are, that can easily remove about 10 pounds of nervous stress from your head.

3. You?re introduced as their future son or daughter-in-law: This makes it official.? You?re no longer the ?girlfriend? or ?boyfriend? in their eyes; you?re now the in-law.? Whether or not you and your love are simply dating or are soon-to-be newlyweds, they hear wedding bells for you two and are already planning your wedding.

How did you tell when your spouse?s parents accepted you?? Share your comments below.

Connect With Cupid...

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Comments

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Auditory Deprivation

Auditory Deprivation ? Can my hearing get worse if I don?t wear hearing aids?

?

Auditory deprivation refers to a person?s lack of adequate hearing stimulation.? Studies have shown, with time, the ability to process sound into meaningful words such as speech can deteriorate if there is not adequate stimulation to the brain. The hearing levels don?t necessarily get worse by not wearing hearing aids, but the ability to understand speech and process the information can deteriorate. This is known as Auditory Deprivation. We are depriving the auditory system in the brain of receiving adequate sound stimulation and our brain gets? lazy?.

?

With auditory deprivation, the brain gradually loses some of its information processing ability.? Several investigations have shown that people, who wear only one hearing aid, experience a reduction in their ability to understand speech in the ear that has not been stimulated with a hearing aid.? The ability of the auditory system to process speech declines due to a lack of stimulation to the ear that was not fitted with a hearing aid.

Many of my clients ask if wearing hearing aids will make their hearing worse like wearing glasses. This is not the case with hearing and as mentioned above, not wearing hearing aids can cause our auditory system to deteriorate. The hearing aids will not make the hearing levels worse.

?

Many individuals with hearing loss wait many years before they try hearing aids.? This may be due to denial, negative stories about hearing aids, stigma or cost.

They have gone for a long time without stimulation to both ears and their ability to understand speech may be poor.?If a hearing loss is present in both ears there are advantages of wearing two hearing aids such as improved sound localisation and better hearing in background noise.? However, another benefit of wearing two hearing aids is to reduce the effects of Auditory Deprivation. The old expression ?use it or lose it? seems to apply to our ability to hear and understand speech.

?

For a confidential discussion with an Audiologist regarding your hearing, call AudioLogic Hearing Services on 9754 4162.

?

http://www.audiologic.net.au/

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Thawing permafrost may have led to extreme global warming events

Public release date: 4-Apr-2012
[ | E-mail | Share ]

Contact: Paul Mannion
P.F.Mannion@sheffield.ac.uk
44-114-222-9851
University of Sheffield

Scientists analysing prehistoric global warming say thawing permafrost released massive amounts of carbon stored in frozen soil of Polar Regions exacerbating climate change through increasing global temperatures and ocean acidification.

Although the amounts of carbon involved in the ancient soil-thaw scenarios was likely much greater than today, the implications of this ground-breaking study are that the long-term future of carbon deposits locked into frozen permafrost of Polar Regions are vulnerable to climate warming caused as humans emit the greenhouse gas carbon dioxide by burning fossil fuels for energy generation.

Researchers in centres across America, Italy and the University of Sheffield, analysed a series of sudden, and extreme, global warming events - called hyperthermals - that occurred about 55 million years ago, linked to rising greenhouse gas concentrations and changes in Earth's orbit, which led to a massive release of carbon into the atmosphere, ocean acidification, and a five degrees Celsius rise in global temperature within just a few thousand years.

It was previously thought that the source of carbon was in the ocean, in the form of frozen methane gas in ocean-floor sediments but now the experts believe the carbon released into the atmosphere millions of years ago came from the Polar Regions.

Professor David Beerling, of the University of Sheffield's Department of Animal and Plant Sciences, said: "For the first time, we have linked these past global warming events with a climatically sensitive terrestrial carbon reservoir rather than a marine one. It shows that global warming can be amplified by carbon release from thawing permafrost."

"The research suggests that carbon stored in permafrost stocks today in the Arctic region is vulnerable to warming. Warming causes permafrost thaw and decomposition of organic matter releasing more greenhouse gases back into the atmosphere.

"This feedback loop could accelerate future warming. It means we must arrest carbon dioxide emissions released by the combustion of fossil fuels if humanity wishes to avoid triggering these sorts of feedbacks in our modern world."

The breakthrough was made through cross-disciplinary collaborations with climate and vegetation modellers, isotope geochemists and permafrost experts led by Rob DeConto at the University of Massachusetts, in collaboration with the University of Sheffield, Yale, the University of Colorado, Penn State, and the University of Urbino, Italy.

Rob DeConto added: "Similar dynamics are at play today. Global warming is degrading permafrost in the north Polar Regions, unlocking once-frozen carbon and methane and releasing it into the atmosphere. This will only exacerbate future warming in a positive feedback loop."

The temperature of Earth's atmosphere is a result of energy input from the sun minus what escapes back into space. Carbon dioxide in the atmosphere absorbs and traps heat that would otherwise return to space.

The global warming events were accompanied by a massive input of carbon to the atmosphere plus ocean acidification, and were characterized by a global temperature rise of about five degrees Celsius within a few thousand years.

Until now, scientists have been unable to account for the massive amounts of carbon required to cause such dramatic global warming events and Antarctica, which on today's Earth is covered by kilometres of ice, has not been appreciated as an important player in such global carbon dynamics.

The research is published in the journal Nature.

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 4-Apr-2012
[ | E-mail | Share ]

Contact: Paul Mannion
P.F.Mannion@sheffield.ac.uk
44-114-222-9851
University of Sheffield

Scientists analysing prehistoric global warming say thawing permafrost released massive amounts of carbon stored in frozen soil of Polar Regions exacerbating climate change through increasing global temperatures and ocean acidification.

Although the amounts of carbon involved in the ancient soil-thaw scenarios was likely much greater than today, the implications of this ground-breaking study are that the long-term future of carbon deposits locked into frozen permafrost of Polar Regions are vulnerable to climate warming caused as humans emit the greenhouse gas carbon dioxide by burning fossil fuels for energy generation.

Researchers in centres across America, Italy and the University of Sheffield, analysed a series of sudden, and extreme, global warming events - called hyperthermals - that occurred about 55 million years ago, linked to rising greenhouse gas concentrations and changes in Earth's orbit, which led to a massive release of carbon into the atmosphere, ocean acidification, and a five degrees Celsius rise in global temperature within just a few thousand years.

It was previously thought that the source of carbon was in the ocean, in the form of frozen methane gas in ocean-floor sediments but now the experts believe the carbon released into the atmosphere millions of years ago came from the Polar Regions.

Professor David Beerling, of the University of Sheffield's Department of Animal and Plant Sciences, said: "For the first time, we have linked these past global warming events with a climatically sensitive terrestrial carbon reservoir rather than a marine one. It shows that global warming can be amplified by carbon release from thawing permafrost."

"The research suggests that carbon stored in permafrost stocks today in the Arctic region is vulnerable to warming. Warming causes permafrost thaw and decomposition of organic matter releasing more greenhouse gases back into the atmosphere.

"This feedback loop could accelerate future warming. It means we must arrest carbon dioxide emissions released by the combustion of fossil fuels if humanity wishes to avoid triggering these sorts of feedbacks in our modern world."

The breakthrough was made through cross-disciplinary collaborations with climate and vegetation modellers, isotope geochemists and permafrost experts led by Rob DeConto at the University of Massachusetts, in collaboration with the University of Sheffield, Yale, the University of Colorado, Penn State, and the University of Urbino, Italy.

Rob DeConto added: "Similar dynamics are at play today. Global warming is degrading permafrost in the north Polar Regions, unlocking once-frozen carbon and methane and releasing it into the atmosphere. This will only exacerbate future warming in a positive feedback loop."

The temperature of Earth's atmosphere is a result of energy input from the sun minus what escapes back into space. Carbon dioxide in the atmosphere absorbs and traps heat that would otherwise return to space.

The global warming events were accompanied by a massive input of carbon to the atmosphere plus ocean acidification, and were characterized by a global temperature rise of about five degrees Celsius within a few thousand years.

Until now, scientists have been unable to account for the massive amounts of carbon required to cause such dramatic global warming events and Antarctica, which on today's Earth is covered by kilometres of ice, has not been appreciated as an important player in such global carbon dynamics.

The research is published in the journal Nature.

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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Afghan bomb kills 10, including 3 from NATO

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Analyze And obtain A Suitable Pet Insurance Now

by Destinyt naran
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Pet insurance is an especially vital facet when it involves your pet's health and welfare. There is repeatedly where you've got to pay lots of cash for medical care, even one thing as straightforward as an everyday check up. When it's one thing a lot of serious, the value skyrockets even a lot of. In fact, your pet's medical bills might even be an equivalent as yours from time to time. Pet insurance will facilitate scale back the value and build it probably that your pet receives the medical care it deserves. Therefore, once you rummage around for a decent pet insurance set up make certain you search as you'd for your own medical insurance set up.

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